Solitary Extramedullary Plasmacytoma of the Liver without Systemic Monoclonal Gammopathy

Extramedullary plasmacytoma of the liver is a very rare tumor. Although a few cases of extramedullary plasmacytoma of the liver have been reported, we could not find any report on truly localized extramedullary plasmacytoma of the liver in the literature. The patient was a 63-yr-old man who exhibited a solitary liver mass on dynamic computed tomography and magnetic resonance imaging. Histologically, the tumor was composed of mature plasma cells with mild atypia. Immunohistochemistry demonstrated monoclonal IgG and Kappa light chain expression. Bone marrow examination revealed no abnormalities. There was no evidence of a monoclonal protein in the serum and urine, lytic bone lesions, anemia, renal insufficiency, and hypercalcemia. The patient was treated with 5,000 cGy of radiotherapy, and the tumor disappeared 6 months after treatment.

Anticorpos contra glicolípides e glicoproteínas em neuropatias periféricas e doença do neurônio motor imunomediadas / Anti-glycopilid and anti-gycoprotein antibodies in peripheral neuropathies and in immunomediated motor neuron disorders

Os anticorpos contra glicolípides e glicoproteínas ocorrem em títulos elevados em doenças do neurônio motor e neuropatias periféricas. Inicialmente foram observados em neuropatias crônicas desmielinizantes com anti-corpos séricos de classe IgM que aparecem contra a glicoproteína da mielina (MAG). Os anticorpos contra gangliosídeos, fraçäo GMI, aparecem freqüentemente, também, em doenças do neurônio motor e neuropatias periféricas. Os anticorpos contra sulfatídeos podem ocorrer em polineuropatias idiopáticas, axonais, sensitivo-motoras, porém predominantemente sensitivas. Os anticorpos contra a proteína de desenvolvimento neuronal Hu, anti-Hu, se associam a glanglionopatias sensitivas paraneoplásicas; assim como as polineuropatias paraneoplásicas frequentemente revelam anticorpos contra o antígeno p-26

Biochemical abnormalities in multiple myeloma

Monoclonial gammopathies can either be benign or more commonly malignant. The commonest disease associated with it is multiple myeloma. Over the seven-year period 1984-1990, two hundred and thirty-four monoclonal gammopathies were seen at the University Hospital, Jamaica. Multiple myeloma was diagnosed in one hundred and fifty-six cases (84 males and 72 females). The diagnosis of most of the others were not known as the samples came from other institution. Of the patients with myeloma, the most common immunoglobulin type was IgG followed by IgA and then pure light chain disease. Only in about half of the cases where urine was analysed was Bence-Jones protien found. The majority of the cases had abnormal total serum protein, albumin and total globulin concentrations. Most of the cases also were in renal failure. Hypercalcaemia, hyperphoshataemia, elevated alkaline phosphate, gammaglutamyl transferase and aspartate aminotransferase occured in about one-third of them. These results were not much different from those reported in other countries

Gammapatías monoclonales: análisis de 26 casos / Monoclonal gammaoathies: analysis of 26 cases

Se analizan 26 casos de gammapatías monoclonales, presentados en pacientes del Hospital Regional de talca, en los últimos seis años. Se muestra el tipo de patología y frecuencia con que se presentaron 21 casos de gammapatía monoclonal maligna (G.M.M.) y 5 casos de gammapatía monoclonal benigna (G.M.B.). La distribución según sexo y edad es analizada en cada grupo. Se muestran las características inmunológicas (clase de inmunoglobulina, migración electroforética y nivel sérico de componente monoclonal) y hematológicas (anemia, leucopenia y trombopenia) presentadas en las G.M.N. y G.M.B. estudiadas